Ribotoxic Stress Response: Activation of the Stress-Activated Protein Kinase JNK1 by Inhibitors of the Peptidyl Transferase Reaction and by Sequence-Specific RNA Damage to the a-Sarcin/Ricin Loop in the 28S rRNA
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alpha-sarcin/ricin loop in the 28S rRNA. and by sequence-specific RNA damage to the inhibitors of the peptidyl transferase reaction stress-activated protein kinase JNK1 by Ribotoxic stress response: activation of the
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A Novel Zak Knockout Mouse with a Defective Ribotoxic Stress Response
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The c-Jun N-terminal kinases (JNKs) are classic stress-activated protein kinases. Many cellular stresses have been shown to stimulate JNK activation. In this review, we focus on ribotoxic stresses based on their multiple biological potencies including anti-HIV-1 activity. Some of the functions of ribotoxins and the signaling transduction pathway that mediated are mentioned. Different from other...
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Translational inhibitors such as the trichothecene mycotoxin deoxynivalenol (DON) and ribosomal inhibitory proteins (RIPs) induce mitogen-activated protein kinase (MAPK)-driven chemokine and cytokine production by a mechanism known as the ribotoxic stress response (RSR). Double-stranded RNA-activated protein kinase (PKR) associates with the ribosome making it uniquely positioned to sense 28S ri...
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تاریخ انتشار 1997